PLASMA PHOSPHATASE

The Plasma Phosphatase in Rickets and Scurvy.

Plasma cell acid phosphatase in multiple myeloma.

In a recent issue of Blood, Saeed et all reported about the prognostic significance of plasma cell acid phosphatase (PCAP) in a large number of patients with multiple myeloma, showing that a low PCAP score (< 130) at diagnosis might recognize a subgroup of myelomatous patients with poor prognosis. I believe that such findings are quite surprising in view of the previously published cumulative d...

Plasma alkaline phosphatase isoenzymes in hepatobiliary disease.

BY CELLULOSE ACETATE OR ACRYLAMIDE GEL ELECTROPHORESIS IT IS POSSIBLE TO SEPARATE THESE ALKALINE PHOSPHATASE ISOENZYMES FROM SERUM: [anode] fast liver, slow liver, placenta/Regan, bone, intestine, bile [cathode]. Heat or chemical inhibition can confirm the differentiation. Normal adult serum always contains slow-liver isoenzyme, and sometimes bone isoenzyme: the latter is always present in seru...

Plasma Cell Acid Phosphatase in Multiple Myeloma

In a recent issue of Blood, Saeed et all reported about the prognostic significance of plasma cell acid phosphatase (PCAP) in a large number of patients with multiple myeloma, showing that a low PCAP score (< 130) at diagnosis might recognize a subgroup of myelomatous patients with poor prognosis. I believe that such findings are quite surprising in view of the previously published cumulative d...

Alkaline phosphatase isoenzymes in plasma in hyperthyroidism.

Alkaline phosphatase (ALP; EC 3.1.3.1) isoenzymes were measured in the plasma of 63 untreated hyperthyroid patients (the hyperthyroid group), 58 treated hyperthyroid patients, and 100 blood donors. Total, liver, and bone ALP activities were significantly higher in the hyperthyroid group than in the treated hyperthyroid group or the blood donors. Bone ALP was more frequently and more markedly ab...